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Research outline - Department of Nuclear Medicine

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Research program

The research program in 2008/09 relates to:

  1. Review and comparison of PET/CT with Conventional Imaging in Paediatric Lymphoma
  2. Review and comparison of PET/CT with Conventional Imaging in Primary Bone Tumours
  3. Application of PET/CT for Tumour Surveillance in paediatric patients with Neurofibromatosis type 1
  4. Application of PET/CT in Neurofibromatosis type 1 patients with optic gliomas and assessment of F18FDG cerebral metabolism
  5. Review of Lymphoscintigraphy in paediatric patients
  6. Radio pharmacy (Westmead Hospital and CHW)
    a. Development of 68Ga-labelled glucosamine for brain tumour imaging in an animal model
    b. Application of 68Ga-Citrate and 68Ga-labelled transferrin (PET) in the diagnostic imaging of Staph aureus induced infection in an animal model.
    c. Development of 99mTc-labelled MIBG-EC for imaging of neuroblastoma in animal model
    d. Development of 68Ga-labelled MIBG-DOTA for imaging of neuroblastoma in animal model
    e. Studying the effect of PTH (Parathyroid Hormone) in the redistribution of 14C-ZA (Zoledronate) in the developing bones of an animal model
  7. Bone Mineral Density & Body Composition (Nuclear Medicine in collaboration with Clinical Departments)
    a. Insulin Resistance/Weight Loss Programme RESIST (Dietary Intervention & Insulin Resistance) Insulin Resistance & Vibration Therapy
    b. Neurofibromatosis Type 1 Bone health study
    c. Osteogenesis imperfecta POISE - Risedronate therapy in mild OI
    d. Gastroenterology Body Composition studies: Crohns disease, Juvenile dermatomyositis, Anorexia Nervosa (& Controls) 4-Compartment model of Body Composition
    e. Adolescent Medicine: Hospitalisation vs Outpatient Therapy for weight restoration in AN
    f. Various Vibration Therapy studies: Mitochondrial Respiratory Chain Disorders, OI, cystic fibrosis
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Research support (2008/09)

Department of Oncology, The Children's Hospital at Westmead
London K
($40,000 over 1 year)

Westmead Hospital and CHW
Fulton R, Howman-Giles R
NHMRC Development grant ($186,000)

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