Associate Professor Jennifer Byrne

Associate Professor
Paediatrics & Child Health, Children's Hospital, Westmead

C29 - Children's Hospital Westmead
The University of Sydney
NSW 2006 Australia

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Biographical details

Career Chronology [More...]

Career Chronology

Jennifer Byrne undertook her PhD with Professor Peter Smith in the University of Queensland's Department of Pathology from 1989-1992. She then spent 3 years in Professor Paul Basset's laboratory in Strasbourg, France as a NH&MRC-funded CJ Martin postdoctoral fellow. She returned to Australia in 1996 to the Children's Medical Research Institute, and then moved to the Children's Cancer Research Unit at The Children's Hospital at Westmead in 1998. She was appointed Acting Head of the Children's Cancer Research Unit in 2008.

Research Highlights

Since first identifying the tumor protein D52 gene in 1995 (Cancer Res. 55: 2896-903), A/Prof Byrne's work has presented a sequence of original discoveries, including identifying other D52-like genes in human and mouse and thereby a novel gene family (Genomics 35: 523-32), heteromeric interactions between D52-like proteins (Oncogene 16: 873-82), 14-3-3 proteins (J. Mol. Biol. 332: 675-687) and the novel MAL2 protein as partners for D52-like proteins (Genomics 76: 81-88), cell cycle regulation of D52-like protein expression in breast carcinoma cells (Exp. Cell Res. 310: 152-165), and frequent D52 overexpression in breast (Genes Chrom. Cancer 29: 48-57), prostate (Cancer Res. 64: 3814-3822) and ovarian cancer (Int. J. Cancer 117: 1049-1054), in part through gene amplification. A/Prof Byrne has also authored the first reviews of D52-like protein expression and function (Biochem Biophys Res Comm 325: 1115-1121, and references below). Over the last 10 years, her work has been supported by project grants and fellowships of a total value of $1,360,000, including a Cancer Institute NSW Career Development fellowship.

Administrative Roles

A/Prof Byrne has been a member of the Cancer Biology NHMRC Grant Review Panel in 2006 and 2007, and previously acted as a member of Specialty Committee B (Cell Biology) for the National Ranking of Cancer Research Grants, from 2002-2004. She is now Chair of the CMRI/Children's Hospital at Westmead Institutional Biosafety Committee. A/Prof Byrne is also convenor of the Sydney Branch and Member of the National Executive of the Women in Science Enquiry Network.

Postgraduate Teaching

Jennifer Byrne is a Conjoint Associate Professor and Deputy Postgraduate Co-ordinator in the Discipline of Paediatrics and Child Health at the University of Sydney. She is also the Faculty of Medicine's conference chair representing for the 2008 From Cell to Society postgraduate student conference. A/Prof Byrne has supervised 4 higher degree students and 5 BSc/ MBBS (Hons) students to completion, and is currently supervising 2 PhD students and 1 BSc (Hons) student. In recognition of her contributions to postgraduate teaching and her own achievements in postgraduate student supervision, she was awarded both the University of Sydney's College of Health Sciences and Faculty of Medicine Awards for Excellence in postgraduate research student supervision for 2005. A/Prof Byrne was previously awarded the University of Sydney Discipline of Paediatrics and Child Health Teaching Award for postgraduate teaching and supervision in 2003. [Hide detail]

Research interests

Jennifer Byrne is a molecular biologist based at the Children’s hospital at Westmead in the Oncology Research Unit. She studies the functions of amplification target genes which are overexpressed in multiple cancers, and the clinical significance of target gene overexpression.

Publications

2011 | 2010 | 2009 | 2008 | 2007 | 2006

2011

Machado, I., López-Guerrero, J., Calabuig-Fariñas, S., Hardy, J., Scotlandi, K., Picci, P., Byrne, J., Llombart-Bosch, A. (2011), Clinical significance of tumor protein D52 immunostaining in a large series of Ewing's sarcoma family of tumors. Pediatric and Developmental Pathology. , 255-256. [Abstract]

2010

Andrés-Delgado, L., Antón, O., Madrid, R., Byrne, J., Alonso, M. (2010), Formin INF2 regulates MAL-mediated transport of Lck to the plasma membrane of human T lymphocytes. Blood. 116(26), 5919-5929. [Abstract]
Madrid, R., Aranda, J., Rodríguez-Fraticelli, A., Ventimiglia, L., Andrés-Delgado, L., Shehata, M., Fanayan, S., Shahheydari, H., Gómez, S., Jiménez, A., Martín-Belmonte, F., Byrne, J., Alonso, M. (2010), The formin INF2 regulates basolateral-to-apical transcytosis and lumen formation in association with Cdc42 and MAL2. Developmental Cell. 18(5), 814-827. [Abstract]
Edo De Bock, C., Lin, Z., Mekkawy, A., Byrne, J., Wang, Y. (2010), Interaction between urokinase receptor and heat shock protein MRJ enhances cell adhesion. International Journal of Oncology. 36(5), 1155-1163. [Abstract]
Thomas, D., Martin, C., Weng, N., Byrne, J., Groblewski, G. (2010), Tumor protein D52 expression and Ca2+-dependent phosphorylation modulates lysosomal membrane protein trafficking to the plasma membrane. American Journal of Physiology: Cell Physiology. 298(3), C725-C739. [Abstract]
Byrne, J., Maleki, S., Hardy, J., Gloss, B., Murali, R., Scurry, J., Fanayan, S., Emmanuel, C., Hacker, N., Sutherland, R., Defazio, A., O'Brien, P. (2010), MAL2 and tumor protein D52 (TPD52) are frequently overexpressed in ovarian carcinoma, but differentially associated with histological subtype and patient outcome. BMC Cancer. 10, 497. [Abstract]

2009

Lewis, J., Sullivan, L., Byrne, J., de Riese, W., Bright, R. (2009), Memory and cellular immunity induced by a DNA vaccine encoding self antigen TPD52 administered with soluble GM-CSF. Cancer Immunology, Immunotherapy. 58(8), 1337-1349. [Abstract]
Alagaratnam, S., Hardy, J., Lothe, R., Skotheim, R., Byrne, J. (2009), TPD52, a candidate gene from genomic studies, is overexpressed in testicular germ cell tumours. Molecular and cellular endocrinology. 306(0), 75-80. [Abstract]
Weidenhofer, J., Byrne, J. (2009), Isolation of Nucleic Acids from Hard Tissues. In: Handbook of Nucleic Acid Purification. (pp.427-448).United States: CRC Press.
Fanayan, S., Shehata, M., Agterof, A., McGuckin, M., Alonso, M., Byrne, J. (2009), Mucin 1 (MUC1) is a novel partner for MAL2 in breast carcinoma cells. BMC Cell Biology. 10(0), 7. [Abstract]

2008

Shehata, M., Bièche, I., Boutros, R., Weidenhofer, J., Fanayan, S., Spalding, L., Zeps, N., Byth, K., Bright, R., Lidereau, R., Byrne, J. (2008), Nonredundant Functions for Tumor Protein D52-Like Proteins Support Specific Targeting of TPD52. Clinical Cancer Research. 14(16), 5050-5060. [Abstract]
Payton, L., Lewis, J., Byrne, J., Bright, R. (2008), Vaccination with metastasis-related tumor associated antigen TPD52 and CpG/ODN induces protective tumor immunity. Cancer Immunology, Immunotherapy. 57(6), 799-811. [Abstract]
Shehata, M., Weidenhofer, J., Thamotharampillai, K., Hardy, J., Byrne, J. (2008), Tumor protein D52 overexpression and gene amplification in cancers from a mosaic of microarrays. Critical Reviews in Oncogenesis. 14(1), 33-55. [Abstract]

2007

Yang, L., Lewis, J., Bright, R., Smith, D., Byrne, J., Whitford, J., Payton, L. (2007), Induction of tumorigenesis and metastasis by the murine orthologue of tumor protein D52. Molecular Cancer Research. 5(2), 133-144. [Abstract]

2006

Barbaric, D., Byth, K., Dalla-Pozza, L., Byrne, J. (2006), Expression of tumor protein D52-like genes in childhood leukemia at diagnosis: Clinical and sample considerations. Leukemia research. 30, 1355-63. [Abstract]

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