Associate Professor Stephen Alexander

Associate Professor
Paediatrics & Child Health, Children's Hospital, Westmead

C29 - Children's Hospital Westmead
The University of Sydney
NSW 2006 Australia

T:+61 2 9845 3430
F:+61 2 9845 3432
E:

Publications

2011 | 2010 | 2009 | 2008 | 2007 | 2006

2011

  
  • Bishop, G., Sharland, A., Ierino, F., Sandrin, M., Hall, B., Alexander, S., Coates, P., McCaughan, G. (2011), Operational Tolerance in Organ Transplantation Versus Tissue Engineering: Into the Future. Transplantation. 92(8), e39. [Abstract]
  • Cao, Q., Wang, C., Zheng, D., Wang, Y., Lee, V., Wang, Y., Zheng, G., Tan, T., Yu, D., Alexander, S., Harris, D., Wang, Y. (2011), IL-25 Induces M2 Macrophages and Reduces Renal Injury in Proteinuric Kidney Disease. Journal of the American Society of Nephrology : JASN. 22(7), 1229-39. [Abstract]
  • Bishop, G., Ierino, F., Sharland, A., Hall, B., Alexander, S., Sandrin, M., Coates, P., McCaughan, G. (2011), Approaching the Promise of Operational Tolerance in Clinical Transplantation. Transplantation. 91(10), 1065-1074. [Abstract]
  • Wang, C., Cordoba, S., Hu, M., Bertolino, P., Bowen, D., Sharland, A., Allen, R., Alexander, S., McCaughan, G., Bishop, G. (2011), Spontaneous acceptance of mouse kidney allografts is associated with increased Foxp3 expression and differences in the B and T cell compartments. Transplant immunology. 24(3), 149-56. [Abstract]
  • Zheng, D., Wang, Y., Cao, Q., Lee, V., Zheng, G., Sun, Y., Tan, T., Wang, Y., Alexander, S., Harris, D. (2011), Transfused Macrophages Ameliorate Pancreatic and Renal Injury in Murine Diabetes Mellitus. Nephron. Experimental nephrology. 118(4), e87-99. [Abstract]
  • Schwensen, K., Burgess, J., Graf, N., Alexander, S., Harris, D., Phillips, J., Rangan, G. (2011), Early Cyst Growth Is Associated with the Increased Nuclear Expression of Cyclin D1/Rb Protein in an Autosomal-Recessive Polycystic Kidney Disease Rat Model. Nephron. Experimental nephrology. 117(4), e93-103. [Abstract]

2010

  
  • Nankivell, B., Alexander, S. (2010), Rejection of the kidney allograft. New England Journal of medicine. 363(15), 1451-1462. [Abstract]
  • Cao, Q., Wang, Y., Zheng, D., Sun, Y., Wang, Y., Lee, V., Zheng, G., Tan, T., Ince, J., Alexander, S., Harris, D. (2010), IL-10/TGF-{beta}-Modified Macrophages Induce Regulatory T Cells and Protect against Adriamycin Nephrosis. Journal of the American Society of Nephrology : JASN. 21(6), 933-42. [Abstract]
  • Ginn, S., Liao, S., Dane, A., Hu, M., Hyman, J., Finnie, J., Zheng, M., Cavazzana-Calvo, M., Alexander, S., Thrasher, A., Alexander, I. (2010), Lymphomagenesis in SCID-X1 Mice Following Lentivirus-mediated Phenotype Correction Independent of Insertional Mutagenesis and gammac Overexpression. Molecular therapy : the journal of the American Society of Gene Therapy. 18(5), 965-76. [Abstract]
  • Sedger, L., Katewa, A., Pettersen, A., Osvath, S., Farrell, G., Stewart, G., Bendall, L., Alexander, S. (2010), Extreme lymphoproliferative disease and fatal autoimmune thrombocytopenia in FasL- and TRAIL-double deficient mice. Blood. 115(16), 3258-68. [Abstract]
  • Lee, V., Qin, X., Wang, Y., Zheng, G., Wang, Y., Wang, Y., Ince, J., Tan, T., Kairaitis, L., Alexander, S., Harris, D. (2010), The CD40-CD154 co-stimulation pathway mediates innate immune injury in adriamycin nephrosis. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association. 25(3), 717-30. [Abstract]

2009

  
  • Albaramki, J., Teo, J., Alexander, S. (2009), Rituximab therapy in two children with autoimmune thrombotic thrombocytopenic purpura. Pediatric nephrology (Berlin, Germany). 24(9), 1749-52. [Abstract]
  • Fletcher, J., Nankivell, B., Alexander, S. (2009), Chronic allograft nephropathy. Pediatric nephrology (Berlin, Germany). 24(0), 1465-71. [Abstract]
  • Watson, D., Hu, M., Zhang, G., Wang, Y., Alexander, S. (2009), Tolerance induction by removal of alloreactive T cells: in-vivo and pruning strategies. Current Opinion in Organ Transplantation. 14(4), 357-363. [Abstract]
  • Zheng, G., Lyons, J., Tan, T., Wang, Y., Hsu, T., Min, D., Succar, L., Rangan, G., Hu, M., Henderson, B., Alexander, S., Harris, D. (2009), Disruption of E-Cadherin by Matrix Metalloproteinase Directly Mediates Epithelial-Mesenchymal Transition Downstream of Transforming Growth Factor-{beta}1 in Renal Tubular Epithelial Cells. The American journal of pathology. 175(2), 580-91. [Abstract]
  • Watson, D., Zheng, G., Wu, H., Wang, Y., Wang, Y., Harris, D., Alexander, S. (2009), CCL2 DNA vaccine to treat renal disease. The international journal of biochemistry & cell biology. 41(0), 729-32. [Abstract]
  • Zhang, G., Hu, M., Wang, Y., Alexander, S. (2009), Foxp3 as a marker of tolerance induction versus rejection. Current Opinion in Organ Transplantation. 14(1), 40-45. [Abstract]
  • Wang, Y., Alexander, S. (2009), CD8 regulatory T cells: what's old is now new. Immunology and cell biology. 87(3), 192-193. [Abstract]

2008

  
  • Lee, V., Wang, Y., Wang, Y., Zheng, D., Polhill, T., Cao, Q., Wu, H., Alexander, I., Alexander, S., Harris, D. (2008), Regulatory immune cells in kidney disease. American journal of physiology. Renal physiology. 295(2), F335-42. [Abstract]
  • Hu, M., Watson, D., Zhang, G., Graf, N., Wang, Y., Sartor, M., Howden, B., Fletcher, J., Alexander, S. (2008), Long-term cardiac allograft survival across an MHC mismatch after "pruning" of alloreactive CD4 T cells. Journal of immunology (Baltimore, Md. : 1950). 180(10), 6593-6603. [Abstract]
  • Williams, G., Fletcher, J., Alexander, S., Craig, J. (2008), Vesicoureteral reflux. Journal of the American Society of Nephrology : JASN. 19(5), 847-862. [Abstract]
  • Hodson, E., Alexander, S. (2008), Evaluation and management of steroid-sensitive nephrotic syndrome. Current Opinion in Pediatrics. 20(2), 145-150. [Abstract]
  • Fernandez, M., Puttur, F., Wang, Y., Howden, W., Alexander, S., Jones, C. (2008), T regulatory cells contribute to the attenuated primary CD8+ and CD4+ T cell responses to herpes simplex virus type 2 in neonatal mice. Journal of Immunology. 180(3), 1556-1564. [Abstract]
  • Alexander, S., Smith, N., Hu, M., Verran, D., Shun, A., Dorney, S., Smith, A., Webster, B., Shaw, P., Lammi, A., Stormon, M. (2008), Chimerism and tolerance in a recipient of a deceased-donor liver transplant. The New England Journal of Medicine. 358(4), 369-374. [Abstract]
  • Wang, Y., Hu, M., Wang, Y., Polhill, T., Zhang, G., Wang, Y., Lee, V., Harris, D., Alexander, S. (2008), Regulatory T cells in renal disease. International Journal of Clinical and Experimental Medicine. 1(4), 294-304. [Abstract]

2007

  
  • Ganesan, P., Alexander, S., Watson, D., Logan, G., Zhang, G., Alexander, I. (2007), Robust anti-tumor immunity and memory in Rag-1-deficient mice following adoptive transfer of cytokine-primed splenocytes and tumor CD80 expression. Cancer immunology, immunotherapy : CII. 56(12), 1955-65. [Abstract]
  • Wu, H., Chen, G., Wyburn, K., Yin, J., Bertolino, P., Eris, J., Alexander, S., Sharland, A., Chadban, S. (2007), TLR4 activation mediates kidney ischemia/reperfusion injury. The Journal of clinical investigation. 117(10), 2847-59. [Abstract]
  • Wang, Y., Wang, Y., Zheng, G., Lee, V., Ouyang, L., Chang, D., Mahajan, D., Coombs, J., Wang, Y., Alexander, S., Harris, D. (2007), Ex vivo programmed macrophages ameliorate experimental chronic inflammatory renal disease. Kidney international. 72(3), 290-9. [Abstract]
  • Wu, H., Wang, Y., Wang, Y., Hu, M., Zhang, G., Knight, J., Harris, D., Alexander, S. (2007), Depletion of gammadelta T cells exacerbates murine adriamycin nephropathy. Journal of the American Society of Nephrology : JASN. 18(4), 1180-1189. [Abstract]
  • Alexander, S., Fletcher, J., Nankivell, B. (2007), Chronic allograft nephropathy in paediatric renal transplantation. Pediatric nephrology (Berlin, Germany). 22, 17-23. [Abstract]

2006

  
  • Fletcher, J., Graf, N., Scarman, A., Saleh, H., Alexander, S. (2006), Nephrotoxicity with cyclooxygenase 2 inhibitor use in children. Pediatric nephrology (Berlin, Germany). 21, 1893-7. [Abstract]
  • Lee, V., Wang, Y., Qin, X., Wang, Y., Zheng, G., Mahajan, D., Coombes, J., Rangan, G., Alexander, S., Harris, D. (2006), Adriamycin nephropathy in severe combined immunodeficient (SCID) mice. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association. 21, 3293-8. [Abstract]
  • Qin, X., Lee, V., Wang, Y., Zheng, G., Wang, Y., Alexander, S., Harris, D. (2006), A protective role for programmed death 1 in progression of murine adriamycin nephropathy. Kidney international. 70, 1244-50. [Abstract]
  • Mahajan, D., Wang, Y., Qin, X., Wang, Y., Zheng, G., Wang, Y., Alexander, S., Harris, D. (2006), CD4+CD25+ Regulatory T Cells Protect against Injury in an Innate Murine Model of Chronic Kidney Disease. Journal of the American Society of Nephrology : JASN. 17(10), 2731-41. [Abstract]
  • Seddiki, N., Santner-Nanan, B., Martinson, J., Zaunders, J., Sasson, S., Landay, A., Solomon, M., Selby, W., Alexander, S., Nanan, R., Kelleher, A., de St Groth, B. (2006), Expression of interleukin (IL)-2 and IL-7 receptors discriminates between human regulatory and activated T cells. The Journal of experimental medicine. 203(7), 1693-700. [Abstract]
  • Wang, Y., Zhang, G., Wang, Y., Hu, M., Wu, H., Watson, D., Harris, D., Alexander, S. (2006), T cell vaccination protects against active Heymann nephritis: A CD8 T cell mechanism. Immunology and Cell Biology. 84(3), A3-A3. [Abstract]
  • Hu, M., Kramer, B., Zhang, G., McCowage, G., Alexander, I., Gunning, P., Alexander, S. (2006), Long term skin allograft survival in mice with MGMT chimeric bone marrow engraftment. Immunology and Cell Biology. 84(3), A29-A29. [Abstract]
  • Wang, C., Cordoba, S., Bertolino, P., Alexander, S., Wu, M., Allen, R., McCaughan, G., Bishop, G. (2006), Examination of the immune mechanism of spontaneous tolerance of renal allografts in a mouse model. Immunology and Cell Biology. 84(3), A29-A30. [Abstract]
  • Wu, H., Chen, G., Wyburn, K., Afifi, M., Yin, J., Eris, J., Alexander, S., Sharland, A., Chadban, S. (2006), TLR4 activation mediates kidney ischemia reperfusion injury. Immunology and Cell Biology. 84(3), A29-A29. [Abstract]
  • Seddiki, N., Santner-Nanan, B., Tangye, S., Alexander, S., Solomon, M., Lee, S., Nanan, R., Fazekas de St Groth, B. (2006), Persistence of naive CD45RA+ regulatory T cells in adult life. Blood. 107, 2830-8. [Abstract]
  • Zheng, G., Zheng, L., Wang, Y., Wu, H., Kairaitis, L., Zhang, C., Tay, Y., Wang, Y., Alexander, S., Harris, D. (2006), NK cells do not mediate renal injury in murine adriamycin nephropathy. Kidney international. 69(7), 1159-65. [Abstract]
  • Seddiki, N., Santner-Nanan, B., Tangye, S., Alexander, S., Solomon, M., Lee, S., Nanan, R., Fazekas de St Groth, B. (2006), Persistence of naive CD45RA(+) regulatory T cells in adult life. Blood. 107(7), 2830-2838. [Abstract]
  • Wang, Y., Zhang, G., Wang, Y., Hu, M., Wu, H., Watson, D., Hori, S., Alexander, I., Harris, D., Alexander, S. (2006), Foxp3-transduced polyclonal regulatory T cells protect against chronic renal injury from adriamycin. Journal of the American Society of Nephrology : JASN. 17(3), 697-706. [Abstract]
  • Zheng, G., Wang, Y., Xiang, S., Tay, Y., Wu, H., Watson, D., Coombes, J., Rangan, G., Alexander, S., Harris, D. (2006), DNA vaccination with CCL2 DNA modified by the addition of an adjuvant epitope protects against "nonimmune" toxic renal injury. Journal of the American Society of Nephrology : JASN. 17(2), 465-74. [Abstract]

Current national competitive grants*

2012

Role of purines in renal and transplant injury
Alexander S, Dwyer K, Wang Y
NHMRC Project Grants ($539,610 over 3 years)

TOLERANCE OR REJECTION ? THE ROLE OF INNATE IMMUNITY IN DETERMINNG THE FATE OF A KIDNEY ALLOGRAFT
Chadban S, Wu H, Alexander S
NHMRC Project Grants ($489,255 over 3 years)

Defining the contribution of skin gamma delta T cells to cutaneous immunosurveillance, immunity and disease after HSV infection
Jones C, Alexander S
NHMRC Project Grants ($581,010 over 3 years)

2010

Gamm-Delta Tregs, CD8 Tregs and selected natural Tregs to treat renal injury
Alexander S, Harris D, Wang Y, Wang Y
NHMRC Project Grant ($583,500 over 3 years)

Gene therapy, stress haematopoiesis and the risk of malignancy
Alexander I, Alexander S, McCormack M, Thrasher A, Ginn S
NHMRC Project Grant ($595,500 over 3 years)

* Grants administered through the University of Sydney