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Research outline - Centre for Kidney Research

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Research program

There are a number of research groupings within the Centre for Kidney Research. Membership of the groupings overlaps extensively, and the research methodologies which are employed include clinical trials, cohort studies, systematic reviews and meta-analyses, epidemiological surveys, questionnaires and qualitative methods such as focus groups, laboratory studies, use of human blood and tissue samples and animal models.

Our current research includes:

  • Aboriginal Health
    • ARDAC [Antecedents for Renal Disease in Aboriginal Children]
    • SEARCH [Study of Environment on Aboriginal Resilience and Child Health]
  • Cancer & Kidney Disease
  • CARI Guidelines [Caring for Australasians with Renal Impairment]
  • Continence Research
    • NEAT study
    • Voiding disorders in children
  • Cochrane Renal Group
  • Support for people with chronic kidney disease[CKD]
  • Getting Research into Practice
  • STEP [Screening and Test Evaluation Program]
    • FEVER Study
    • Monitoring
    • Diagnostic tests

Our laboratory is looking at rejection and tolerance of kidney transplants and the possible causes and treatment of a variety of renal diseases, including those with genetic causes and developing new treatments for atherosclerosis, a major problem in patients with kidney disease.

  • Glomerulonephritis Research
  • Renal Genetics
  • Transplantation Research
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Research support (2008/09)

Clinical

Antecedents of renal disease in Aboriginal children and young
adults – 12 years follow-up
Craig J, Hodson E, Lyle D, Yarnold D, Roy P, Haysom L
NHMRC Project Grant No 512248 ($1,738,125 over 5 years)

Improving population health by a multidisciplinary, multi-method focus kidney disease of the young, the old, and of Indigenous Australians
Craig J, Cass A, Irwig L, Chadban S, McDonald S, Devitt J, Macaskill P, Jones M, Howard K, Salkeld G
NHMRC Capacity Building Grant in Population Health No. 457281 ($2,465,750 over 5 years)

Screening and Test Evaluation Program (STEP)
Irwig L, Craig J, Salkeld G, Macaskill P, McCaffery K
NHMRC Program Grant No. 402764 ($6.44 million over 5 years)

SEARCH – Study of Environment on Aboriginal Resilience and Child Health
Craig J, Taylor R, Bailey S, Banks E, Cass A, Clapham K, Daniels J, Eades S, Kippax S, McIntyre P, Parker A, Raphael B, Redman S, Vincent F
NHMRC Aboriginal and Torres Strait Islander Research A Healthy Start to Life initiative (ID 358457) ($2,043,110 over 5 years)

Australasian Kidney Trials
Hawley C, Kerr P, Hoy W, Nicol D, Cass A, Beller E, Craig J
(AKT) Network – ID 338800 NHMRC Enabling ($1,290,000 over 5 years)

Antecedents of Renal Disease in Aboriginal and Non-Aboriginal Children and Young Adults (a 12- year follow-up study)
Craig J
ARDAC second phase study – The Financial Markets Foundation for Children ($134,684 over 2 years)

Cardio-renal effects of renin angiotensin system inhibitionin cardiorenal patients: comparative randomized trial of angiotensin converting enzyme inhibitors, angiotensin receptor blockers or their combination in patients with one or more cardiovascular risk factors, screen positive for proteinuria, diabetic or not diabetic and with mild/moderate impairment of renal function. The cardio-renal protection trial.
Strippoli G, Craig J C, Nicolucci A, Pellegrini F, Tognoni G, Palasciano G, Gesualdo L
Agenzia Italiana del Farmaco (AIFA)-Italy (Rome, Via della Sierra Nevada 60, CF 2009 97345810580, PI 09703841000) (2,250,000.00 euros over 3 years)

Funding for Australian based Cochrane Collaboration activities: the Cochrane renal group
Craig J C
2005-2008 Commonwealth Department of Health & Aged Care ($240,000)

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Laboratory

Treatment of Diverse Renal Diseases with Regulatory Cells
Harris D C H, Alexander S I, Wang Y-P, Wang Y-M
NHMRC Project Grant 457408 ($607,530 over 3 years)

The development of a National Centre for Clinical Islet Transplantation
One of 3 CIs on the laboratory analysis of islet recipients
JDRF International Islet Transplant Program in Australia ($8 million over 4 years)

The Genomics of Chronic Allograft Rejection
Murphy B, O'Connell P J, Gallon L, Samaniego M, Najafian N, Colvin R
NIH NIDDK NIH RFA # U01 AI 070107-01 (US$5.9 million over 6 years)

Kidney transplantation: Improving Outcomes
Alexander S I, Bishop G A, Sharland A F
NHMRC Project Grant ($427,500 over 3 years)

Tregs in Herpes Infection
Jones C, Cunningham T, Alexander SI
ARC ($547,492 over 3 years)

Vaccination Protects Against Cardiac Fibrosis
Edgely A, Harris D C, Alexander S I, Kelly D
DART Grant CCL2 ($57,000 over 2 years)

Primed T cells in graft rejection
Fazekas de St Groth BD, Alexander SI, Levidiotis V
NHMRC Project Grant 570780 ($521,250 over 3 years)

DNA vaccination for chronic kidney disease
Harris D C, Alexander S I, Wang Y, Wang Y M
NHMRC Project Grant 571343 ($432,750 over 3 years)

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