Key Publications

Cyclin-dependent kinase 7 is a therapeutic target in high-grade glioma.  Greenall, S., Lim, Y., Mitchell, C., Ensbey, K., Stringer, B., Wilding, A., O'Neill, G., McDonald, K., Gough, D., Day, B., et al Oncogenesis 2017 6(5), 1-13.

Rac GTPase regulation of 3D invasion in neuroblastomas lacking MYCN amplification. Mitchell, C., O'Neill, G. Cell Adhesion and Migration, 2017 11(1), 68-79.

The focal adhesion targeting domain of p130Cas confers a mechanosensing function. Bradbury PM, Turner K, Mitchell C, Griffin KR, Middlemiss S, Lau L, Dagg R, Taran E, Cooper-White J, Fabry B, O'Neill GM.  J Cell Sci. 2017 130(7):1263-1273.

Cooperative cell invasion: matrix metalloproteinase-mediated incorporation between cells. Mitchell CB, O'Neill GM.  Mol Biol Cell. 2016 27(21):3284-3292

Differential response of patient-derived primary glioblastoma cells to environmental stiffness. Grundy TJ, De Leon E, Griffin KR, Stringer BW, Day BW, Fabry B, Cooper-White J, O'Neill GM.  Sci Rep. 2016 Mar 21;6:23353.

Tropomyosin Tm5NM1 spatially restricts src kinase activity through perturbation of Rab11 vesicle trafficking. Bach CT, Murray RZ, Owen D, Gaus K, O'Neill GM.  Mol Cell Biol. 2014 34(24):4436-46.

Src kinase determines the dynamic exchange of the docking protein NEDD9 (neural precursor cell expressed developmentally down-regulated gene 9) at focal adhesions. Bradbury P, Bach CT, Paul A, O'Neill GM. J Biol Chem. 2014 289(36):24792-800.

NEDD9 stabilizes focal adhesions, increases binding to the extra-cellular matrix and differentially effects 2D versus 3D cell migration.  Zhong J, Baquiran JB, Bonakdar N, Lees J, Ching YW, Pugacheva E, Fabry B, O'Neill GM. PLoS One. 2012;7(4):e35058.

The actin-associating protein Tm5NM1 blocks mesenchymal motility without transition to amoeboid motility.  Lees JG, Bach CT, Bradbury P, Paul A, Gunning PW, O'Neill GM. Oncogene. 2011 30(10):1241-51.

Tropomyosin isoform expression regulates the transition of adhesions to determine cell speed and direction. Bach CT, Creed S, Zhong J, Mahmassani M, Schevzov G, Stehn J, Cowell LN, Naumanen P, Lappalainen P, Gunning PW, O'Neill GM. Mol Cell Biol. 2009 29(6):1506-14.

A full list of publications can be found here