Recent key publications - Gene Therapy Research Unit
Logan G.J., Wang L., Zheng M., Cunningham S.C., Coppel R.L. and Alexander I.E. (2007) AAV vectors encoding malarial antigens stimulate transgene-specific immunity but do not protect from parasite infection. Vaccine 25(6):1014-1022, epub 9th October 2006.
Cooper S.T., Kizana E., Yates J.D., Lo H.P., Yang N., Wu Z.H., Alexander I.E. and North K.N. (2007) Dystrophinopathy carrier determination and dectection of protein deficie in muscular dystrophy using lentiviral MyoD-forced myogenesis. Neuromuscular Disorders 17(4):276-284, epub 13th February 2007.
Yu Z-Y., McKay K., van Asperen P., Zheng M., Fleming J., Ginn S.L., Kizana E., Latham M., Feneley M.P., Kirkland P.D., Lumbers E.R. and Alexander I.E. (2007) Lentivirus vector-mediated gene transfer to the developing bronchiolar airway epithelium in the fetal lamb. Journal of Gene Medicine 9(6):429-439, epub 5th April, 2007.
Smyth C.M., Ginn S.L., Deakin C.T., Logan G.J. and Alexander I.E. (2007) Limiting c expression differentially affects signaling via the interleukin (IL)-7 and IL-15 receptors. Blood 110(1):91-98, epub 15th March 2007.
Kizana E., Chang C.Y., Cingolani E., Ramirez-Correa G.A., Sekar R.B., Abraham M.R., Ginn S.L., Tung L., Alexander I.E. and Marban E. (2007) Gene Transfer of Connexin43 Mutants Attenuates Coupling in Cardiomyocytes: Novel Basis for Modulation of Cardiac Conduction by Gene Therapy. Circulation Research 100(11):1597-1604, epub 10th May, 2007.
Deichmann A., Hacein-Bey Abina S., Schmidt M., Garrigue A., Brugman M., Hu J., Glimm H., Gyapay G., Prum B., Fraser C.C., Fischer N., Schwarzwaelder K., Siegler M-L., de Ridder D., Pike-Overzet K., Howe S.J., Thrasher A.J., Wagemaker G., Abel U., Staal F., Delabesse E., Villeval J-L., Aronow B., Hue C., Prinz C., Wissler M., Klanke C., Weissenbach J., Alexander I., Fischer A., von Kalle C. and Cavazzana-Calvo M. (2007) Vector integration is non-random, clustered and influences the in vivo fate of lymphopoiesis in SCID-X1 gene therapy. Journal of Clinical Investigation 117(8):2225-2232.
Ganesan P.L., Alexander S.I., Watson D., Logan G.J., Zhang G.Y., and Alexander I.E. (2007) Robust anti-tumor immunity and memory in Rag-1-deficient mice following adoptive transfer of cytokine-primed splenocytes and tumor CD80 expression. Cancer Immunology Immunotherapy 56(12):1955-1965, epub 5th June, 2007.
Baoutina, A., Alexander, I.E., Rasko, J.E.J., and Emslie, K.R. (2007). Potential use of gene therapy in athletic performance enhancement. Molecular Therapy 15(10):1751-1766, epub 7th August, 2007.
Baoutina, A., Alexander, I.E., Rasko, J.E.J., and Emslie, K.R. (2008). Developing strategies for detection of gene doping. Journal of Gene Medicine 10(1):3-20.
Curtin J.A., Dane A.P., Swanson A., Alexander I.E. and Ginn S.L. (2008) Bi-directional promoter interference between two widely used internal heterologous promoters in a late-generation lentiviral construct. Gene Therapy 15(5):384–390, epub 24th January, 2008.
Alexander I.E., Cunningham S.C., Logan G.L. and Christodoulou J. (2008) Potential of AAV Vectors in the Treatment of Metabolic Disease. Invited Review. Gene Therapy 15(11):831-839, epub 10th April, 2008.
Cunningham S.C., Dane A.P., Spinoulas A., Logan G.J. and Alexander I.E. (2008) Gene delivery to the juvenile mouse liver using AAV2/8 vectors. Molecular Therapy 16(6):1081-1088, epub 15th April, 2008.
Lee V.W., Wang Y-M., Wang Y-P, Zheng D., Polhill T., Cao Q., Wu H., Alexander I.E., Alexander S.I. and Harris D.C. (2008) Regulatory immune cells in kidney disease. American Journal of Physiology: Renal Physiology 295(2):F335-342, epub 16th April, 2008.
Ginn S.L. and Alexander I.E. (2008) Gene Therapy. In: Wiley Encyclopedia of Clinical Trials. John Wiley & Sons, Inc., New Jersey, Eds. D'Agostino R., Sullivan L., Massaro J.
Laurence J.M., Wang C., Cunningham S.C., Zheng M., Earl J., Tay S.S., Allen R.D.M., McCaughan G.W., Alexander I.E., Bishop G.A. and Sharland A.F. (2009) Over-expression of indoleamine dioxygenase in rat liver allografts using a high-efficiency adeno-associated virus vector does not prevent acute rejection. Liver Transplantation 15(2):233-241.
Logan G.J., Wang L., Zheng M., Ginn S.L., Coppel R.L. and Alexander I.E. (2009) Antigen-specific humoral tolerance or immune augmentation induced by intramuscular delivery of adeno associated virus encoding CTLA4-Ig-antigen fusion molecules. Gene Therapy 16(2):200-210, epub 27th November, 2008.
Lee A.S.J., Kahatapitiya P., Kramer B., Joya J.E., Hook J., Liu R., Schevzov G., Alexander I.E., McCowage G., Montarras D., Gunning P.W. and Hardeman E.C. (2009) Methylguanine DNA methyltransferase-mediated drug resistance-based selective enrichment and engraftment of transplanted stem cells in skeletal muscle. Stem Cells 27(5):1098-1108, epub 5th February, 2009.
Liu R., Ginn S.L., Lek M., North K.N., Alexander I.E., Little D.G. and Schindeler A. (2009) Myoblast sensitivity and fibroblast insensitivity to osteogenic conversion by BMP-2 correlates with the expression of Bmpr-1a. BMC musculoskeletal disorders, 10: 51, 15th May.
Ginn S.L., Cunningham S.C., Zheng M., Spinoulas A., Carpenter K.H. and Alexander I.E. (2009) In vivo assessment of mutations in OTC for dominant-negative effects following rAAV2/8-mediated gene delivery to the mouse liver. Gene Therapy 16(6): 820-823, epub 9th April, 2009.
Laurence J.M., Allen R.D.M., McCaughan G.W., Logan G.J., Alexander I.E., Bishop G.A., Sharland A.F. (2009) Gene Therapy in Transplantation. Transplantation Reviews 23(3):159-170, epub 8th May,2009.
Cunningham S.C., Spinoulas A., Carpenter K., Wilcken B., Kuchell P. and Alexander I.E. (2009) AAV2/8-mediated correction of OTC deficiency is robust in adult but not neonatal spfash mice. Molecular Therapy, 17(8):1340-1346, epub 21st April 2009.
Dane A.P., Cunningham S.C., Graf N.S. and Alexander I.E. (2009) Sexually Dimorphic Patterns of Episomal rAAV Genome Persistence in the Adult Mouse Liver and Correlation with Hepatocellular Proliferation. Molecular Therapy, 17(9):1548-1554, epub 30th June, 2009.
Deakin C., Alexander I.E. and Kerridge I. (2009) Accepting Risk in Clinical Research: Is Gene Therapy Becoming Too Risk-Averse? Molecular Therapy, accepted 1st September 2009.
