Key Publications

Smith RH*, Hallwirth CV*, Westerman M, Hetherington NA, Tseng Y, Cecchini S, Virag T, Ziegler M, Rogozin IB, Koonin EV, Agbandje-McKenna M, Kotin RM and Alexander IE (2016) Germline viral “fossils” guide in silico reconstruction of a mid-Cenozoic era marsupial adeno-associated virus. Scientific Reports. Online 5th July; 6:28965 DOI: 10.1038/srep28965

Hallwirth C, Garg G, Peters T, Kramer B, Malani NV, Hyman J, Ruan X, Ginn SL, Hetherington NA, Veeravalli L, Shahab A, Ranganathan S, Wei C, Liddle C, Thrasher A, Bushman FD, Buckley M and Alexander IE (2015) Coherence analysis discriminates between retroviral integration patterns in CD34+ cells transduced under differing clinical trial conditions. Molecular Therapy - Methods & Clinical Development eCollection Apr 29; 2:15015

Cunningham SC, Siew S, Hallwirth CV, Bolitho C, Sasaki N, Garg G, Michael IP, Hetherington NA, Carpenter K, de Alencastro G, Nagy A and Alexander IE (2015) Modeling Correction of Severe Urea Cycle Defects in the Growing Murine Liver using a Hybrid rAAV/piggyBac Transposase Gene Delivery System. Hepatology 62(2):417-428

Deyle DR, Hansen SR, Li LB, Burt AA, Cornea AM, Alexander IE, Stamatoyannopoulos J, Wei C-L and Russell DW (2014) A Genome-Wide Map of Human Gene Targeting. Nature Structural & Molecular Biology 21(11):969-975

Deakin CT, Alexander IE, Deakin JJ, Ginn SL, Young P, Humphries D, Suter CM and Hallwirth CV (2014) Impact of next generation sequencing error on the analysis of barcoded plasmid libraries of known complexity and sequence. Nucleic Acids Research 42(16):e129

Tay SS, McDonald D, Wood NA, Roediger B, Sierro F, McGuffog CM, Alexander IE, Bishop GA, Weninger W, McCaughan GW, Bertolino P and Bowen DG (2014) Antigen expression level threshold tunes the fate of CD8 T cells during primary hepatic immune responses. Proc. Natl. Acad. Sci. USA 111(25):E2540-E2549

Lisowski L, Dane AP, Chu K, Zhang Y, Cunningham SC, Wilson EM, Nygaard S, Grompe M, Alexander IE and Kay MA (2014) Selection and evaluation of clinically relevant AAV variants in a xenograft liver model. Nature 506(7488):382-386

Kojima Y, Kaufman-Francis K, Studdert JB, Steiner KA, Power MD, Loebel DAF, Jones V, Hor A, de Alencastro G, Logan G, Teber ET, Tam OH, Stutz MD, Alexander IE, Pickett HA and Tam PPL (2014) The transcriptional and functional properties of mouse epiblast stem cells resemble the anterior primitive streak. Cell Stem Cells 13:1-14

Kok CY, Cunningham SC, Carpenter KH, Dane AP, Siew SM, Logan GJ, Kuchel PW and Alexander IE (2013) Adeno-associated virus-mediated rescue of neonatal lethality in argininosuccinate synthetase deficient mice. Molecular Therapy 21(10):1823-1831

Deakin CT, Alexander IE, Hooker CA and Kerridge IH (2013)  Gene therapy researchers’ assessments and perceptions of risks in clinical trials. Molecular Therapy 21(4): 806-815