Associate Professor Geraldine O'Neill

Associate Professor
Paediatrics & Child Health, Children's Hospital, Westmead

C29 - Children's Hospital Westmead
The University of Sydney
NSW 2006 Australia

T:02 9845 1206
F:02 9845 3078
E:

W:Related website

Biographical details

A/Prof O'Neill has attracted ~$2.3M in peer-reviewed funding from national (NHMRC), specialist(Cancer Council and Cancer Institute NSW) and local agencies in the last 5 years and since 2006 was lead or co-investigator on successful equipment and infrastructure grants (>$2M). She has contributed 39 research publications, with over 900 citations and research from her laboratory is regularly presented at national (~5/year) and international conferences (1/year). Awards include NHMRC Howard Florey Post-doctoral Fellowship (2000-2002) and the NSW Cancer Council [More...]

Research interests

The central theme of A/Prof Geraldine O'Neill's research is to understand how cancer cell interaction with the surrounding matrix leads to the progression to metastatic disease, one of the major causes of cancer patient mortality. Her team investigates the cell biology of cancer cell invasion, with a particular focus on brain tumours and neuroblastoma.

Publications

2012 | 2011 | 2010 | 2009 | 2008 | 2007 | 2006

2012

  
  • Bradbury, P., Mahmassani, M., Zhong, J., Turner, K., Paul, A., Verrills, N., O'Neill, G. (2012), PP2A phosphatase suppresses function of the mesenchymal invasion regulator NEDD9. Biochimica et biophysica acta. 1823(2), 290-7. [Abstract]

2011

  
  • Shum, M., Pasquier, E., Po'uha, S., O'Neill, G., Chaponnier, C., Gunning, P., Kavallaris, M. (2011), γ-Actin regulates cell migration and modulates the ROCK signaling pathway. The FASEB Journal. 25(12), 4423-4433. [Abstract]
  • Kopecki, Z., O'Neill, G., Arkell, R., Cowin, A. (2011), Regulation of focal adhesions by flightless i involves inhibition of paxillin phosphorylation via a Rac1-dependent pathway. The Journal of Investigative Dermatology. 131(7), 1450-1459. [Abstract]
  • Lees, J., Bach, C., Bradbury, P., Paul, A., Gunning, P., O'Neill, G. (2011), The actin-associating protein Tm5NM1 blocks mesenchymal motility without transition to amoeboid motility. Oncogene. 30, 1241-51. [Abstract]
  • Bradshaw, L., Zhong, J., Bradbury, P., Mahmassani, M., Smith, J., Ammit, A., O'Neill, G. (2011), Estradiol stabilizes the 105kD phospho-form of the adhesion docking protein NEDD9 and suppresses NEDD9-dependent cell spreading in breast cancer cells. Biochimica et biophysica acta. 1813(2), 340-5. [Abstract]
  • Lees, J., Bach, C., O'Neill, G. (2011), Interior decoration: Tropomyosin in actin dynamics and cell migration. Cell adhesion & migration. 5(2), 181-6. [Abstract]
  • O'Neill, G. (2011), Scared stiff: Stabilizing the actin cytoskeleton to stop invading cancer cells in their tracks. Bioarchitecture. 1(1), 29-31. [Abstract]

2010

  
  • Bach, C., Schevzov, G., Bryce, N., Gunning, P., O'Neill, G. (2010), Tropomyosin isoform modulation of focal adhesion structure and cell migration. Cell adhesion & migration. 4(2), 226-34. [Abstract]
  • Zhong, J., Paul, A., Kellie, S., O'Neill, G. (2010), Mesenchymal migration as a therapeutic target in glioblastoma. Journal of Oncology. 2010, 430142. [Abstract]

2009

  
  • Bach, C., Creed, S., Zhong, J., Mahmassani, M., Schevzov, G., Stehn, J., Cowell, L., Naumanen, P., Lappalainen, P., Gunning, P., O'Neill, G. (2009), Tropomyosin isoform expression regulates the transition of adhesions to determine cell speed and direction. Molecular and cellular biology. 29(6), 1506-14. [Abstract]
  • Garron, M., Arsenieva, D., Zhong, J., Bloom, A., Lerner, A., O'Neill, G., Arold, S. (2009), Structural insights into the association between BCAR3 and Cas family members, an atypical complex implicated in anti-oestrogen resistance. Journal of molecular biology. 386(1), 190-203. [Abstract]
  • O'Neill, G. (2009), The coordination between actin filaments and adhesion in mesenchymal migration. Cell adhesion & migration. 3(4), 355-7. [Abstract]

2008

  
  • O'neill, G., Stehn, J., Gunning, P. (2008), Tropomyosins as interpreters of the signalling environment to regulate the local cytoskeleton. Seminars in cancer biology. 18(1), 35-44. [Abstract]
  • Schevzov, G., Fath, T., Vrhovski, B., Vlahovich, N., Rajan, S., Hook, J., Joya, J., Lemckert, F., Puttur, F., Lin, J., Hardeman, E., Wieczorek, D., O'Neill, G., Gunning, P. (2008), Divergent regulation of the sarcomere and the cytoskeleton. The Journal of biological chemistry. 283(1), 275-83. [Abstract]
  • Schevzov, G., O'Neill, G. (2008), Tropomyosin gene expression in vivo and in vitro. Advances in experimental medicine and biology. 644(0), 43-59. [Abstract]
  • Gunning, P., O'Neill, G., Hardeman, E. (2008), Tropomyosin-based regulation of the actin cytoskeleton in time and space. Physiological Reviews. 88(1), 1-35. [Abstract]

2007

  
  • O'neill, G., Seo, S., Serebriiskii, I., Lessin, S., Golemis, E. (2007), A New Central Scaffold for Metastasis: Parsing HEF1/Cas-L/NEDD9. Cancer research. 67(19), 8975-9. [Abstract]
  • Singh, M., Cowell, L., Seo, S., O'neill, G., Golemis, E. (2007), Molecular basis for HEF1/NEDD9/Cas-L action as a multifunctional co-ordinator of invasion, apoptosis and cell cycle. Cell biochemistry and biophysics. 48(1), 54-72. [Abstract]

2006

  
  • Cowell, L., Graham, J., Bouton, A., Clarke, C., O'neill, G. (2006), Tamoxifen treatment promotes phosphorylation of the adhesion molecules, p130Cas/BCAR1, FAK and Src, via an adhesion-dependent pathway. Oncogene. 25, 7597-607. [Abstract]
  • Stehn, J., Schevzov, G., O'Neill, G., Gunning, P. (2006), Specialisation of the tropomyosin composition of actin filaments provides new potential targets for chemotherapy. Current cancer drug targets. 6(3), 245-56. [Abstract]

Current national competitive grants*

2010

The cell biology of glioblastoma infiltration
O'Neill G
NHMRC Project Grant ($508,225 over 3 years)

* Grants administered through the University of Sydney