Professor Chris Cowell

Professor
Paediatrics & Child Health, Children's Hospital, Westmead

C29 - Children's Hospital Westmead
The University of Sydney
NSW 2006 Australia

T:+61 2 9845 3200
F:+61 2 9845 3170
E:

Research interests

Clinical insulin resistance and Type 2 diabetes are new metabolic disorders in children associated with the rise in obesity prevalence. Our group is interested in 1) the relationship between expression of adipocytokines and development of insulin resistance and 2) developing effective interventions by conducting RCT's

Publications

2011 | 2010 | 2009 | 2008 | 2007 | 2006

2011

  
  • Simm, P., Johannesen, J., Briody, J., McQuade, M., Hsu, B., Bridge, C., Little, D., Cowell, C., Munns, C. (2011), Zoledronic acid improves bone mineral density, reduces bone turnover and improves skeletal architecture over 2years of treatment in children with secondary osteoporosis. Bone. 49(5), 939-943. [Abstract]
  • Garnett, S., Baur, L., Cowell, C. (2011), The prevalence of increased central adiposity in Australian school children 1985 to 2007. Obesity reviews : an official journal of the International Association for the Study of Obesity. 12(11), 887-96. [Abstract]
  • Tam, C., Heilbronn, L., Henegar, C., Wong, M., Cowell, C., Cowley, M., Kaplan, W., Clément, K., Baur, L. (2011), An early inflammatory gene profile in visceral adipose tissue in children. International journal of pediatric obesity : IJPO : an official journal of the International Association for the Study of Obesity. 6(2-2), e360-3. [Abstract]
  • Hughes, I., Choong, C., Harris, M., Ambler, G., Cutfield, W., Hofman, P., Cowell, C., Werther, G., Cotterill, A., Davies, P. (2011), Growth hormone treatment for Turner syndrome in Australia reveals that younger age and increased dose interact to improve response. Clinical Endocrinology. 74(4), 473-480. [Abstract]
  • Bridge, P., Pocock, N., Nguyen, T., Munns, C., Cowell, C., Forwood, N., Thompson, M. (2011), Validation of Longitudinal DXA Changes in Body Composition From Pre- to Mid-Adolescence Using MRI as Reference. Journal of Clinical Densitometry. 14(3), 340-347. [Abstract]
  • Tran, F., Vu, D., Nguyen, H., Bui, T., Huynh, L., Nguyen, K., Nguyen, V., Tran, H., Tran, D., Hoang, T., Harkin, N., Armstrong, K., Jameson, K., Pham, A., Chris, C., Maria, C. (2011), Glycaemic control in children with neonatal diabetes and type 1diabetes in Vietnam. International Health. 3(3), 188-192.
  • Xiong, F., Garnett, S., Cowell, C., Biesheuvel, C., Zeng, Y., Long, C., Wang, Q., Wang, D., Luo, Y., Luo, S. (2011), Waist circumference and waist-to-height ratio in Han Chinese children living in Chongqing, south-west China. Public health nutrition. 14(1), 20-6. [Abstract]

2010

  
  • Crawford, B., Cowell, C., Emder, P., Learoyd, D., Chua, E., Sinn, J., Jack, M. (2010), Iodine toxicity from soy milk and seaweed ingestion is associated with serious thyroid dysfunction. The Medical Journal of Australia. 193(7), 413-415. [Abstract]
  • Quinn, S., Baur, L., Garnett, S., Cowell, C. (2010), Treatment of clinical insulin resistance in children: a systematic review. Obesity reviews : an official journal of the International Association for the Study of Obesity. 11(10), 722-30. [Abstract]
  • Garnett, S., Srinivasan, S., Birt, S., Ambler, G., Lawrie, E., Cowell, C., Craig, M. (2010), Evaluation of glycaemic status in young people with clinical insulin resistance; fasting glucose, fasting insulin or an oral glucose tolerance test?. Clinical endocrinology. 72(4), 475-80. [Abstract]
  • Garnett, S., Baur, L., Noakes, M., Steinbeck, K., Woodhead, H., Burrell, S., Chisholm, K., Broderick, C., Parker, R., De, S., Shrinivasan, S., Hopley, L., Hendrie, G., Ambler, G., Kohn, M., Cowell, C. (2010), Researching Effective Strategies to Improve Insulin Sensitivity in Children and Teenagers - RESIST. A randomised control trial investigating the effects of two different diets on insulin sensitivity in young people with insulin resistance and/or pre-diabetes. BMC Public Health. 10, 575. [Abstract]
  • Tam, C., Garnett, S., Cowell, C., Heilbronn, L., Lee, J., Wong, M., Baur, L. (2010), IL-6, IL-8 and IL-10 levels in healthy weight and overweight children. Hormone Research in Paediatrics. 73(2), 128-134. [Abstract]
  • Denney-Wilson, E., Cowell, C., Okely, A., Hardy, L., Aitken, R., Dobbins, T. (2010), Associations between insulin and glucose concentrations and anthropometric measures of fat mass in Australian adolescents. BMC Pediatrics. 10(1), 58. [Abstract]
  • Birke, O., Schindeler, A., Ramachandran, M., Cowell, C., Munns, C., Bellemore, M., Little, D. (2010), Preliminary experience with the combined use of recombinantbone morphogenetic protein and bisphosphonates in the treatmentof congenital pseudarthrosis of the tibia. Journal of Children's Orthopaedics. 4(6), 507–517.

2009

  
  • Johannesen, J., Briody, J., McQuade, M., Little, D., Cowell, C., Munns, C. (2009), Systemic effects of zoledronic acid in children with traumatic femoral head avascular necrosis and Legg-Calve-Perthes disease. Bone. 45(5), 898-902. [Abstract]
  • Bridge, P., Pocock, N., Nguyen, T., Munns, C., Cowell, C., Thompson, M. (2009), Prediction of appendicular skeletal and fat mass in children: excellent concordance of dual-energy X-ray absorptiometry and magnetic resonance imaging. Journal of Pediatric Endocrinology & Metabolism. 22(9), 795-804. [Abstract]
  • Booth, M., Dobbins, T., Aitken, R., Denney-Wilson, E., Hardy, L., Okely, A., George, J., Sullivan, D., Cowell, C. (2009), Costs of managing conditions associated with obesity among Australian teenagers. Journal of paediatrics and child health. 45(0), 448-56. [Abstract]
  • Steinbeck, K., Baur, L., Cowell, C., Pietrobelli, A. (2009), Clinical research in adolescents: challenges and opportunities using obesity as a model. International journal of obesity (2005). 33(0), 2-7. [Abstract]

2008

  
  • Gleeson, H., Wiley, V., Wilcken, B., Elliott, E., Cowell, C., Thonsett, M., Byrne, G., Ambler, G. (2008), Two-year pilot study of newborn screening for congenital adrenal hyperlasia in New South Wales compared with nationwide case surveillance in Australia. Journal of Paediatrics and Child Health. 44(10), 554-559. [Abstract]
  • Maguire, A., Craig, M., Cowell, C. (2008), Management of adrenal insufficiency during the stress of medical illness and surgery.Comment. The Medical journal of Australia. , 350. [Abstract]
  • Kim, L., Holland, A., Srinivasan, S., Cowell, C., Benn, D., Robinson, B. (2008), Paediatric bilateral adrenal phaeochromocytomas in association with a novel mutation in the von Hippel Lindau gene. Journal of paediatrics and child health. 44(9), 514-516. [Abstract]
  • Garnett, S., Baur, L., Cowell, C. (2008), Waist-to-height ratio: a simple option for determining excess central adiposity in young people. International journal of obesity (2005). 32(6), 1028-30. [Abstract]
  • Maguire, A., Biesheuvel, C., Ambler, G., Moore, B., McLean, M., Cowell, C. (2008), Evaluation of adrenal function using the human corticotrophin-releasing hormone test, low dose Synacthen test and 9am cortisol level in children and adolescents with central adrenal insufficiency. Clinical endocrinology. 68(0), 683-91. [Abstract]
  • Wiebe, P., Blimkie, C., Farpour-Lambert, N., Briody, J., Marsh, D., Kemp, A., Cowell, C., Howman-Giles, R. (2008), Effects of single-leg drop-landing exercise from different heights on skeletal adaptations in prepubertal girls: a randomized controlled study. Pediatric Exercise Science. 20(2), 211-228. [Abstract]
  • Högler, W., Blimkie, C., Cowell, C., Inglis, D., Rauch, F., Kemp, A., Wiebe, P., Duncan, C., Farpour-Lambert, N., Woodhead, H. (2008), Sex-specific developmental changes in muscle size and bone geometry at the femoral shaft. Bone. 42(5), 982-989. [Abstract]
  • Gleeson, H., Wiltshire, E., Briody, J., Hall, J., Chaitow, J., Sillence, D., Cowell, C., Munns, C. (2008), Childhood chronic recurrent multifocal osteomyelitis: pamidronate therapy decreases pain and improves vertebral shape. The Journal of Rheumatology. 35(4), 707-712. [Abstract]
  • Zhu, K., Greenfield, H., Zhang, Q., Du, X., Ma, G., Foo, L., Cowell, C., Fraser, D. (2008), Growth and bone mineral accretion during puberty in Chinese girls: a five-year longitudinal study. Journal of Bone and Mineral Research. 23(2), 167-172. [Abstract]
  • Högler, W., Blimkie, C., Rauch, F., Woodhead, H., Cowell, C. (2008), Scaling and adjusting growth-related data and sex-differences in the muscle-bone relation: a perspective. Journal of musculoskeletal & neuronal interactions. 8(1), 25-28. [Abstract]

2007

  
  • Garnett, S., Baur, L., Srinivasan, S., Lee, J., Cowell, C. (2007), Body mass index and waist circumference in midchildhood and adverse cardiovascular disease risk clustering in adolescence. The American journal of clinical nutrition. 86(3), 549-555. [Abstract]
  • Munns, C., Rajab, M., Hong, J., Briody, J., Högler, W., McQuade, M., Little, D., Cowell, C. (2007), Acute phase response and mineral status following low dose intravenous zoledronic acid in children. Bone. 41(3), 366-70. [Abstract]
  • Ramachandran, M., Ward, K., Brown, R., Munns, C., Cowell, C., Little, D. (2007), Intravenous bisphosphonate therapy for traumatic osteonecrosis of the femoral head in adolescents. The Journal of bone and joint surgery. American volume. 89(8), 1727-1734. [Abstract]
  • Maguire, A., Ambler, G., Moore, B., McLean, M., Falleti, M., Cowell, C. (2007), Prolonged hypocortisolemia in hydrocortisone replacement regimens in adrenocorticotrophic hormone deficiency. Pediatrics. 120(1), e164-e171. [Abstract]
  • Dulai, S., Briody, J., Schindeler, A., North, K., Cowell, C., Little, D. (2007), Decreased bone mineral density in neurofibromatosis type 1: results from a pediatric cohort. Journal of pediatric orthopedics. 27(4), 472-475. [Abstract]
  • Kiely, P., Ward, K., Bellemore C, M., Briody, J., Cowell, C., Little, D. (2007), Bisphosphonate rescue in distraction osteogenesis: a case series. Journal of pediatric orthopedics. 27(4), 467-471. [Abstract]
  • Maguire, A., Ambler, G., Moore, B., Waite, K., McLean, M., Cowell, C. (2007), The clinical utility of alternative, less invasive sampling techniques in the assessment of oral hydrocortisone therapy in children and adolescents with hypopituitarism. European journal of endocrinology / European Federation of Endocrine Societies. 156(4), 471-476. [Abstract]
  • Maguire, A., Cowell, C. (2007), Salivary cortisol to assess the hypothalamic-pituitary-adrenal axis in healthy children under 3 years old. Jornal de pediatria. , 383-384. [Abstract]
  • Bachrach, L., Levine, M., Cowell, C., Shaw, N. (2007), Clinical Indications for the Use of DXA in Pediatrics. In: Bone Densitometry in Growing Patients. (pp.59-72).United States: Humana Press.
  • Fung, E., Bachrach, L., Briody, J., Cowell, C. (2007), Reporting DXA Results. In: Bone Densitometry in Growing Patients. (pp.127-136).United States: Humana Press.

2006

  
  • Taplin, C., Cowell, C., Silink, M., Ambler, G. (2006), Fludrocortisone Therapy in Cerebral Salt Wasting. Pediatrics. 118(6), e1904-8. [Abstract]
  • Stone, M., Briody, J., Kohn, M., Clarke, S., Madden, S., Cowell, C. (2006), Bone changes in adolescent girls with anorexia nervosa. The Journal of adolescent health : official publication of the Society for Adolescent Medicine. 39(6), 835-41. [Abstract]
  • Gabbett, M., Jones, K., Cowell, C., Sillence, D., Wilson, M. (2006), Neonatal severe hyperparathyroidism: An important clue to the aetiology. Journal of paediatrics and child health. 42(12), 813-6. [Abstract]
  • Tam, C., de Zegher, F., Garnett, S., Baur, L., Cowell, C. (2006), Opposing Influences of Prenatal and Postnatal Growth on the Timing of Menarche. The Journal of clinical endocrinology and metabolism. 91(11), 4369-73. [Abstract]
  • Munns, C., Zacharin, M., Rodda, C., Batch, J., Morley, R., Cranswick, N., Craig, M., Cutfield, W., Hofman, P., Taylor, B., Grover, S., Pasco, J., Burgner, D., Cowell, C. (2006), Prevention and treatment of infant and childhood vitamin D deficiency in Australia and New Zealand: a consensus statement. The Medical journal of Australia. 185(5), 268-272. [Abstract]
  • Craig, M., Cowell, C., Larsson, P., Zipf, W., Reiter, E., Albertsson Wikland, K., Ranke, M., Price, D. (2006), Growth hormone treatment and adverse events in Prader-Willi syndrome: data from KIGS (the Pfizer International Growth Database). Clinical endocrinology. 65(2), 178-85. [Abstract]
  • Robinson, P., Hogler, W., Craig, M., Verge, C., Walker, J., Piper, A., Woodhead, H., Cowell, C., Ambler, G. (2006), The re-emerging burden of rickets: a decade of experience from Sydney. Archives of Disease in Childhood. 91(7), 564-568. [Abstract]
  • Tam, C., Garnett, S., Cowell, C., Campbell, K., Cabrera, G., Baur, L. (2006), Soft drink consumption and excess weight gain in Australian school students: results from the Nepean study. International Journal of Obesity. 30(7), 1091-3. [Abstract]
  • Robinson, P., Högler, W., Craig, M., Verge, C., Walker, J., Piper, A., Woodhead, H., Cowell, C., Ambler, G. (2006), The re-emerging burden of rickets: A decade of experience from Sydney. Archives of disease in childhood. 91, 564-8. [Abstract]
  • Clarke, S., Craig, M., Garnett, S., Chan, A., Cowell, C., Cusumano, J., Kordonouri, O., Sambasivan, A., Donaghue, K. (2006), Increased adiposity at diagnosis in younger children with type 1 diabetes does not persist. Diabetes care. 29(7), 1651-3. [Abstract]
  • Srinivasan, S., Ambler, G., Baur, L., Garnett, S., Tepsa, M., Yap, F., Ward, G., Cowell, C. (2006), Randomized, controlled trial of metformin for obesity and insulin resistance in children and adolescents: improvement in body composition and fasting insulin. The Journal of clinical endocrinology and metabolism. 91(6), 2074-80. [Abstract]
  • Little, D., Ward, K., Kiely, P., Bellemore, M., Briody, J., Cowell, C. (2006), Bisphosphonate rescue in distraction osteogenesis: A case series. Bone. 38(3), S80-S80. [Abstract]
  • Zhu, K., Zhang, Q., Foo, L., Trube, A., Ma, G., Hu, X., Du, X., Cowell, C., Fraser, D., Greenfield, H. (2006), Growth, bone mass, and vitamin D status of Chinese adolescent girls 3 y after withdrawal of milk supplementation. The American journal of clinical nutrition. 83(3), 714-21. [Abstract]
  • Hardy, L., Baur, L., Garnett, S., Crawford, D., Campbell, K., Shrewsbury, V., Cowell, C., Salmon, J. (2006), Family and home correlates of television viewing in 12-13 year old adolescents: The Nepean Study. The international journal of behavioral nutrition and physical activity [electronic resource]. 3(24), 0. [Abstract]
  • Vimalachandra, D., Hodson, E., Willis, N., Craig, J., Cowell, C., Knight, J. (2006), Growth hormone for children with chronic kidney disease. Cochrane Database of Systematic Reviews. 0(3), 0. [Abstract]
  • Vimalachandra, D., Hodson, E., Willis, N., Craig, J., Cowell, C., Knight, J. (2006), Growth hormone for children with chronic kidney disease. Cochrane database of systematic reviews (Online). 3, CD003264. [Abstract]

Current national competitive grants*

2010

Bisphosphonate Treatment of childhood femoral head avascular necrosis due to Perthes disease
Cowell C, Little D, Munns C, Foster B, Zacharin M
NHMRC Project Grant ($1,305,625 over 5 years)

2009

Sex-related changes in asthma during the transition through puberty in the CAPS birth cohort
Marks G, Toelle B, Leeder S, Cowell C, Tovey E, Almqvist C
NHMRC Project Grants ($783,875 over 5 years)

* Grants administered through the University of Sydney