CKR Laboratory Research Program

Group Leader: Professor Stephen Alexander

Renal transplantation is a life-saving procedure for increasing numbers of children with Chronic Kidney Disease (CKD).

Immune responses play a major role in some of these kidney diseases, as well as tolerance of kidney transplants. Our research is determining the role of regulatory T cells (Tregs) in autoimmune renal disease and transplantation rejection, so that we can find better ways to treat and manage these significant health problems.

We investigate innovative technologies such as gene therapy and DNA vaccination for treatment of CKD, and are attempting to define novel Tregs which more powerfully protect against rejection.

As a research group informed by clinical outcomes we see in the clinic, we also continue to define the incidence of CKD in Australia and New Zealand. We have reported the outcomes for women with kidney transplants having children: a real success story of the last 30 years.