Molecular Oncology

Group leader: Associate Professor Jennifer Byrne

We investigate what happens in cancer at a molecular level. One of the biggest problems in combatting cancer is gene amplification – where cells make multiple copies of a region of the chromosome, leading to unregulated cell proliferation and drug resistance.

We identify and study a number of amplification targets to understand how they contribute to cellular transformation and tumour progression. The ultimate aim is to be able to target these genes with drugs.

We are also involved in two translational research projects supporting pharmacokinetics and molecular diagnostics for childhood cancer patients within the Sydney Children's Hospital Network.

Current laboratory interests include:

  • Molecular and cellular functions for TPD52-like proteins
  • Mapping chromosome 8q amplification events in different tumour types
  • Molecular profiling for factors predicting sensitivity or resistance to therapy in relapsed child cancer