> Defining Regulatory T cell subsets in children in health and disease - CI Dr Peter Hsu
Regulatory T cells (Tregs) are essential for immune tolerance. This study is defining Treg subsets in healthy children and in children with allergy and other immune diseases.
> BEAT: a RCT of early infant feeding for primary prevention of egg allergy - CIs Prof Dianne Campbell, Dr. John Tan
This study is one of only two large randomized controlled trials being conducted in Australia to help prevent egg allergy, which is the most common cause of food allergy in Australia.
> ADDVIT: treatment of atopic dermatitis (eczema) with daily vitamin D- CI Prof Dianne Campbell, Dr Lara Ford
Vitamin D plays important roles in regulating the immune system. This randomized controlled trial is exploring whether Vitamin D ingestion improves the control of eczema, a common and troublesome atopic disorder.
> FISH: characterisation of major fish allergens in Australian children- CIs Prof Dianne Campbell, Prof Andreas Lopata
Australian doctors currently rely upon European fish extracts to diagnose fish allergy. This study is characterising the unique Australian and Pacific fish which cause fish allergy in Australian Children.
> Effects of Diet and Omeprazole in patients with eosinophilic oesophagitis-EoE - AI A/Prof Allyson Kakakios
This is a multicentre study looking at the most effective diets for treatment of children with a serious type of allergy which affects the oesophagus (the tube connecting the mouth to the stomach).
> Understanding Food Protein Induced Enterocolitis Syndrome (FPIES)- CIs Dr Sam Mehr, Prof Dianne Campbell, Eric Lee
This study is examining the pathogenesis of FPIES, which is largely unknown. Understanding FPIES will facilitate better diagnosis and management of this condition.
> BOPI for children with peanut allergy- CIs Prof Dianne Campbell, Dr Melanie Wong, Dr Sam Mehr, Dr Peter Hsu, Prof Ralph Nanan
This is an RCT examining whether boiled peanut oral immunotherapy (rather than roasted or raw peanuts), with or without an adjuvant (a substance that modulates the immune system) may help children outgrow peanut allergy. Suitable participants include children with peanut allergy aged 10-16 years. This NHMRC-funded study will commence no earlier than June 2016. Those interested in participating the study, please email SCHN-BOPIA@health.nsw.gov.au
> Enterocolitis syndrome and eosinophilic esophagitis- CIs Dr Sam Mehr, Dr Katie Frith, Prof Dianne Campbell, APSU
We are investigating new reported cases of these rarer food allergies, and trying to better understand how to recognise, manage and treat these diseases.
> Defining genetic defects in Primary Immunodeficiency Disorders - CI Dr Melanie Wong
> Component Resolved Diagnostics (CRD) in peanut allergy- CIs Prof Dianne Campbell, Dr Sam Mehr
This study examines the use of a range of CRD for diagnosis of peanut allergies in children.