First effective treatment of children with Charcot-Marie-Tooth disease

11 July 2017

The results of a randomised trial to evaluate progressive resistance exercise for children and adolescents with CMT published in The Lancet Child & Adolescent Health showed a difference in strength between the exercise group and the other group was 30%

Among a myriad of motor and sensory impairments, foot and ankle weakness is the most debilitating problem for children with CMT. Muscle weaknesses cause painful foot deformities and lifelong difficulty performing everyday tasks Injuries resulting from trips and falls.

Researchers, led by Prof Joshua Burns,  found that targeted short-term moderate-intensity progressive resistance exercise of the foot dorsiflexors, using an adjustable exercise cuff, was an effective therapeutic strategy to attenuate long-term progression of dorsiflexion weakness without detrimental effect on muscle morphology or other signs of overwork weakness.

The next step is to develop a translation strategy to directly impact clinical practice and improve health outcomes for patients with CMT locally, nationally and internationally.

Josh presented his research findings at the 2017 Peripheral Nerve Society Annual Meeting, Sitges-Barcelona, Spain  on July 10.

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